4rrn: Difference between revisions
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==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors== | ==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors== | ||
<StructureSection load='4rrn' size='340' side='right' caption='[[4rrn]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4rrn' size='340' side='right'caption='[[4rrn]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4rrn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRN FirstGlance]. <br> | <table><tr><td colspan='2'>[[4rrn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UW:(4S,4AS,10AR)-2-AMINO-8-(2-FLUOROPYRIDIN-3-YL)-1-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[IMIDAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-5(1H)-ONE'>3UW</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UW:(4S,4AS,10AR)-2-AMINO-8-(2-FLUOROPYRIDIN-3-YL)-1-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[IMIDAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-5(1H)-ONE'>3UW</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5n|4r5n]], [[4rro|4rro]], [[4rrs|4rrs]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5n|4r5n]], [[4rro|4rro]], [[4rrs|4rrs]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrn OCA], [http://pdbe.org/4rrn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrn RCSB], [http://www.ebi.ac.uk/pdbsum/4rrn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrn OCA], [http://pdbe.org/4rrn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrn RCSB], [http://www.ebi.ac.uk/pdbsum/4rrn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrn ProSAT]</span></td></tr> | ||
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==See Also== | ==See Also== | ||
*[[Beta secretase|Beta secretase]] | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Brown, K D]] | [[Category: Brown, K D]] | ||
