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==Structural Basis of KChIP4a Modulation of Kv4.3 Slow Inactivation==
==Structural Basis of KChIP4a Modulation of Kv4.3 Slow Inactivation==
<StructureSection load='3dd4' size='340' side='right' caption='[[3dd4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3dd4' size='340' side='right'caption='[[3dd4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DD4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DD4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnip4, Calp, Kchip4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnip4, Calp, Kchip4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dd4 OCA], [http://pdbe.org/3dd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dd4 RCSB], [http://www.ebi.ac.uk/pdbsum/3dd4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dd4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dd4 OCA], [https://pdbe.org/3dd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dd4 RCSB], [https://www.ebi.ac.uk/pdbsum/3dd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dd4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KCIP4_MOUSE KCIP4_MOUSE]] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND3/Kv4.3 and KCND2/Kv4.2 currents (By similarity).<ref>PMID:11805342</ref> <ref>PMID:19109250</ref>   
[[https://www.uniprot.org/uniprot/KCIP4_MOUSE KCIP4_MOUSE]] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND3/Kv4.3 and KCND2/Kv4.2 currents (By similarity).<ref>PMID:11805342</ref> <ref>PMID:19109250</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Chai, J]]
[[Category: Chai, J]]
Retrieved from "https://proteopedia.org/3dd4"