4e68: Difference between revisions

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==Unphosphorylated STAT3B core protein binding to dsDNA==
==Unphosphorylated STAT3B core protein binding to dsDNA==
<StructureSection load='4e68' size='340' side='right' caption='[[4e68]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
<StructureSection load='4e68' size='340' side='right'caption='[[4e68]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E68 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E68 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bg1|1bg1]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e68 OCA], [https://pdbe.org/4e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e68 RCSB], [https://www.ebi.ac.uk/pdbsum/4e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e68 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aprf, Stat3, STAT3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e68 OCA], [http://pdbe.org/4e68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e68 RCSB], [http://www.ebi.ac.uk/pdbsum/4e68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e68 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
[[https://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Collie, G W]]
[[Category: Mus musculus]]
[[Category: Parkinson, G N]]
[[Category: Synthetic construct]]
[[Category: Shah, R]]
[[Category: Collie GW]]
[[Category: Activator of transcription]]
[[Category: Parkinson GN]]
[[Category: Cytosol]]
[[Category: Shah R]]
[[Category: Duplex dna]]
[[Category: Nucleus]]
[[Category: Protein dna complex]]
[[Category: Sh2 domain]]
[[Category: Signal transducer]]
[[Category: Transcription-dna complex]]

Revision as of 06:52, 28 September 2022

Unphosphorylated STAT3B core protein binding to dsDNA

4e68, resolution 2.58Å

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