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==Crystal structure of SspH1 LRR domain==
==Crystal structure of SspH1 LRR domain==
<StructureSection load='4nkh' size='340' side='right' caption='[[4nkh]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='4nkh' size='340' side='right'caption='[[4nkh]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nkh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Salt1 Salt1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NKH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nkh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._14028S Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NKH FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nkg|4nkg]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nkh OCA], [https://pdbe.org/4nkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nkh RCSB], [https://www.ebi.ac.uk/pdbsum/4nkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nkh ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sspH1, STM14_1483 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=588858 SALT1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nkh OCA], [http://pdbe.org/4nkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nkh RCSB], [http://www.ebi.ac.uk/pdbsum/4nkh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nkh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref>
[https://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Salt1]]
[[Category: Large Structures]]
[[Category: Keszei, A F.A]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]]
[[Category: Mccormick, C]]
[[Category: Keszei AFA]]
[[Category: Rohde, J R]]
[[Category: Mccormick C]]
[[Category: Sicheri, F]]
[[Category: Rohde JR]]
[[Category: Tyers, M]]
[[Category: Sicheri F]]
[[Category: Xiaojing, T]]
[[Category: Tyers M]]
[[Category: Zeqiraj, E]]
[[Category: Xiaojing T]]
[[Category: E3 ligase substrate interaction domain]]
[[Category: Zeqiraj E]]
[[Category: Leucine-rich repeat]]
[[Category: Ligase]]
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