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==Crystal structure of D48V mutant of human GLTP bound with 12:0 disulfatide (hexagonal form)==
==Crystal structure of D48V mutant of human GLTP bound with 12:0 disulfatide (hexagonal form)==
<StructureSection load='4gvt' size='340' side='right' caption='[[4gvt]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4gvt' size='340' side='right'caption='[[4gvt]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gvt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GVT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GVT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SG:N-{(2S,3R,4E)-1-[(3,6-DI-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]-3-HYDROXYOCTADEC-4-EN-2-YL}DODECANAMIDE'>0SG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SG:N-{(2S,3R,4E)-1-[(3,6-DI-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]-3-HYDROXYOCTADEC-4-EN-2-YL}DODECANAMIDE'>0SG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gix|4gix]], [[4gh0|4gh0]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gvt OCA], [https://pdbe.org/4gvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gvt RCSB], [https://www.ebi.ac.uk/pdbsum/4gvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gvt ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gvt OCA], [http://pdbe.org/4gvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gvt RCSB], [http://www.ebi.ac.uk/pdbsum/4gvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gvt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Cabo-Bilbao, A]]
[[Category: Large Structures]]
[[Category: Goni-de-Cerio, F]]
[[Category: Cabo-Bilbao A]]
[[Category: Malinina, L]]
[[Category: Goni-de-Cerio F]]
[[Category: Popov, A N]]
[[Category: Malinina L]]
[[Category: Samygina, V R]]
[[Category: Popov AN]]
[[Category: Gltp-fold]]
[[Category: Samygina VR]]
[[Category: Lipid transport]]
Retrieved from "https://proteopedia.org/4gvt"