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==Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 103.2 Single Chain Antibody==
==Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 103.2 Single Chain Antibody==
<StructureSection load='4f9p' size='340' side='right' caption='[[4f9p]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
<StructureSection load='4f9p' size='340' side='right'caption='[[4f9p]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f9p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F9P FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f9p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F9P FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BTF5, BTN3A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IgG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f9p OCA], [https://pdbe.org/4f9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f9p RCSB], [https://www.ebi.ac.uk/pdbsum/4f9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f9p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f9p OCA], [http://pdbe.org/4f9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f9p RCSB], [http://www.ebi.ac.uk/pdbsum/4f9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f9p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN]] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>
[https://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Adams, E J]]
[[Category: Mus musculus]]
[[Category: Bonneville, M]]
[[Category: Adams EJ]]
[[Category: Harly, C]]
[[Category: Bonneville M]]
[[Category: Nedellec, S]]
[[Category: Harly C]]
[[Category: Olive, D]]
[[Category: Nedellec S]]
[[Category: Palakodeti, A]]
[[Category: Olive D]]
[[Category: Sandstrom, A]]
[[Category: Palakodeti A]]
[[Category: Scotet, E]]
[[Category: Sandstrom A]]
[[Category: Sundaresan, L]]
[[Category: Scotet E]]
[[Category: B7 superfamily]]
[[Category: Sundaresan L]]
[[Category: Butyrophilin]]
[[Category: Cd277]]
[[Category: Immune system]]
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