3qf2: Difference between revisions

<StructureSection load='3qf2' size='340' side='right' caption='[[3qf2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>

<table><tr><td colspan='2'>[[3qf2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QF2 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NALP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qf2 OCA], [http://pdbe.org/3qf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qf2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qf2 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/NALP3_HUMAN NALP3_HUMAN]] Familial cold urticaria;CINCA syndrome with NLRP3 mutations;Muckle-Wells syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  

[[http://www.uniprot.org/uniprot/NALP3_HUMAN NALP3_HUMAN]] May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.<ref>PMID:11786556</ref> <ref>PMID:14662828</ref>