4lzp: Difference between revisions
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==Structure of the TIR domain of the immunosuppressor BtpA from Brucella== | ==Structure of the TIR domain of the immunosuppressor BtpA from Brucella== | ||
<StructureSection load='4lzp' size='340' side='right' caption='[[4lzp]], [[Resolution|resolution]] 3.15Å' scene=''> | <StructureSection load='4lzp' size='340' side='right'caption='[[4lzp]], [[Resolution|resolution]] 3.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lzp]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4lzp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_melitensis_ATCC_23457 Brucella melitensis ATCC 23457]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LZP FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lzp OCA], [https://pdbe.org/4lzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lzp RCSB], [https://www.ebi.ac.uk/pdbsum/4lzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lzp ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/BTPA_BRUMB BTPA_BRUMB] Virulence factor that interferes with host Toll-like receptor 2 (TLR2) and TLR4 signaling, resulting in the reduction of dendritic cell maturation, inhibition of pro-inflammatory cytokine secretion and impaired NF-kappa-B activation in macrophages (PubMed:18266466). Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown (PubMed:29395922).<ref>PMID:18266466</ref> <ref>PMID:29395922</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Brucella melitensis ATCC 23457]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Kaplan-turkoz B]] | ||
[[Category: | [[Category: O'callaghan D]] | ||
[[Category: Terradot L]] | |||
[[Category: | [[Category: Vergunst A]] | ||
[[Category: | |||
