4b2j

COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS

spinqualitylabelsall models 4b2j, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4b2j is a 1 chain structure with sequence from Hals3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, MG, NA, RBF, SO4 NonStd Res: 4FW Related: 2cc8, 2ccb, 2vx9, 4b2h, 4b2k, 4b2m Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [DODEC_HALS3] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome. Publication Abstract from PubMed Tamed electrons: To manipulate a protein photocycle in a directed manner, the flavoprotein dodecin was endoscopically modified at its key amino acid tryptophan with substituents carefully selected by their structural and electronic influence. The approach is ideal in the precision of rational protein engineering, and allows correlating tryptophan ionization potentials and electron transfer rates in a Marcus model. Directed Manipulation of a Flavoprotein Photocycle.,Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M Angew Chem Int Ed Engl. 2013 Jul 1. doi: 10.1002/anie.201302334. PMID:23818044 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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