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==Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses: molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses==
==Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses: molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses==
<StructureSection load='4eda' size='340' side='right' caption='[[4eda]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4eda' size='340' side='right'caption='[[4eda]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/korea/01/2009(h1n1)) Influenza a virus (a/korea/01/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EDA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Korea/01/2009(H1N1)) Influenza A virus (A/Korea/01/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4edb|4edb]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eda OCA], [https://pdbe.org/4eda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eda RCSB], [https://www.ebi.ac.uk/pdbsum/4eda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eda ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644289 Influenza A virus (A/Korea/01/2009(H1N1))])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eda OCA], [http://pdbe.org/4eda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eda RCSB], [http://www.ebi.ac.uk/pdbsum/4eda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eda ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]  
[[https://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alam, I]]
[[Category: Large Structures]]
[[Category: Cho, K J]]
[[Category: Alam I]]
[[Category: Kang, S H]]
[[Category: Cho KJ]]
[[Category: Khan, T G]]
[[Category: Kang SH]]
[[Category: Kim, K H]]
[[Category: Khan TG]]
[[Category: Lee, J H]]
[[Category: Kim KH]]
[[Category: Lee, J Y]]
[[Category: Lee JH]]
[[Category: Park, Y H]]
[[Category: Lee JY]]
[[Category: Antibody]]
[[Category: Park YH]]
[[Category: Conformation]]
[[Category: Haemagglutinin]]
[[Category: Influenza virus]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/4eda"