4g1o

Crystal structure of Newcastle disease virus matrix protein

spinqualitylabelsall models 4g1o, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4g1o is a 2 chain structure with sequence from Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MATRX_NDVA The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane. Publication Abstract from PubMed Many pleomorphic, lipid-enveloped viruses encode matrix proteins that direct their assembly and budding, but the mechanism of this process is unclear. We have combined X-ray crystallography and cryoelectron tomography to show that the matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimers that assemble into pseudotetrameric arrays that generate the membrane curvature necessary for virus budding. We show that the glycoproteins are anchored in the gaps between the matrix proteins and that the helical nucleocapsids are associated in register with the matrix arrays. About 90% of virions lack matrix arrays, suggesting that, in agreement with previous biological observations, the matrix protein needs to dissociate from the viral membrane during maturation, as is required for fusion and release of the nucleocapsid into the host's cytoplasm. Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly. Structure and assembly of a paramyxovirus matrix protein.,Battisti AJ, Meng G, Winkler DC, McGinnes LW, Plevka P, Steven AC, Morrison TG, Rossmann MG Proc Natl Acad Sci U S A. 2012 Aug 13. PMID:22891297 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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