2xzt

Caspase-3 in Complex with DARPin-3.4_I78S

spinqualitylabelsall models 2xzt, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2xzt is a 6 chain structure with sequence from Human and Miscellaneous nucleic acid. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MRD NonStd Res: CSO Related: 2xzd, 1rhk, 1rhq, 2dko, 2xyp, 2j31, 2cjy, 2xyh, 2cjx, 1re1, 2xyg, 2c1e, 2cno, 1gfw, 1qx3, 1rhm, 1nme, 2j33, 1rhr, 1nms, 1nmq, 1rhj, 2cnn, 2c2k, 2cnl, 2c2m, 1cp3, 2cnk, 2j30, 1pau, 2cdr, 1i3o, 2j32, 1rhu, 2c2o Activity: Caspase-3, with EC number 3.4.22.56 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. See Also Caspase

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