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==Conformational dynamics of exchange protein directly activated by cAMP==
==Conformational dynamics of exchange protein directly activated by cAMP==
<StructureSection load='4f7z' size='340' side='right' caption='[[4f7z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4f7z' size='340' side='right'caption='[[4f7z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F7Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F7Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rapgef4, Cgef2, Epac2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f7z OCA], [https://pdbe.org/4f7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f7z RCSB], [https://www.ebi.ac.uk/pdbsum/4f7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f7z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f7z OCA], [http://pdbe.org/4f7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f7z RCSB], [http://www.ebi.ac.uk/pdbsum/4f7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f7z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE]] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>
[https://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Cheng, X]]
[[Category: Mus musculus]]
[[Category: Liu, T]]
[[Category: Cheng X]]
[[Category: Mei, F C]]
[[Category: Liu T]]
[[Category: Tsalkova, T N]]
[[Category: Mei FC]]
[[Category: White, M A]]
[[Category: Tsalkova TN]]
[[Category: Woods, V L]]
[[Category: White MA]]
[[Category: Auto-inhibition]]
[[Category: Woods VL]]
[[Category: Cdc25 homology domain]]
[[Category: Cyclic nucleotide]]
[[Category: Exchange factor]]
[[Category: Exocytosis]]
[[Category: Gef]]
[[Category: Regulation]]

Revision as of 04:40, 7 October 2022

Conformational dynamics of exchange protein directly activated by cAMP

4f7z, resolution 2.60Å

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