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==Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element==
==Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element==
<StructureSection load='4guq' size='340' side='right' caption='[[4guq]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='4guq' size='340' side='right'caption='[[4guq]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4guq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GUQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4guq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g82|4g82]], [[4g83|4g83]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guq OCA], [https://pdbe.org/4guq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guq RCSB], [https://www.ebi.ac.uk/pdbsum/4guq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guq ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">human p73, P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guq OCA], [http://pdbe.org/4guq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4guq RCSB], [http://www.ebi.ac.uk/pdbsum/4guq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4guq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Ethayathulla, A S]]
[[Category: Large Structures]]
[[Category: Nguyen, H T]]
[[Category: Ethayathulla AS]]
[[Category: Viadiu, H]]
[[Category: Nguyen HT]]
[[Category: Beta-immunoglobulin]]
[[Category: Viadiu H]]
[[Category: Transcription factor]]
[[Category: Transcription-dna complex]]
[[Category: Tumor suppressor]]
Retrieved from "https://proteopedia.org/4guq"