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==Crystal structure of the N-terminal ankyrin repeat domain of TRPV3==
==Crystal structure of the N-terminal ankyrin repeat domain of TRPV3==
<StructureSection load='4n5q' size='340' side='right' caption='[[4n5q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4n5q' size='340' side='right'caption='[[4n5q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n5q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N5Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5Q FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5q OCA], [https://pdbe.org/4n5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5q RCSB], [https://www.ebi.ac.uk/pdbsum/4n5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5q OCA], [http://pdbe.org/4n5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n5q RCSB], [http://www.ebi.ac.uk/pdbsum/4n5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).  
[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4n5q" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4n5q" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Cao, X]]
[[Category: Mus musculus]]
[[Category: Shi, D J]]
[[Category: Cao X]]
[[Category: Wang, K W]]
[[Category: Shi DJ]]
[[Category: Ye, S]]
[[Category: Wang KW]]
[[Category: Zhang, R]]
[[Category: Ye S]]
[[Category: Ankyrin]]
[[Category: Zhang R]]
[[Category: Channel]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/4n5q"