1lum: Difference between revisions
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'''NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures''' | '''NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures''' | ||
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[[Category: Fulton, D B.]] | [[Category: Fulton, D B.]] | ||
[[Category: Mallis, R J.]] | [[Category: Mallis, R J.]] | ||
[[Category: | [[Category: Cis/trans isomerization]] | ||
[[Category: | [[Category: Interleukin-2 tyrosine kinase]] | ||
[[Category: | [[Category: Itk]] | ||
[[Category: | [[Category: Proline]] | ||
[[Category: | [[Category: Sh2]] | ||
[[Category: | [[Category: Src homology 2]] | ||
[[Category: | [[Category: T-cell specific kinase]] | ||
[[Category: | [[Category: Tsk]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:18:30 2008'' | |||
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Revision as of 21:18, 2 May 2008
NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures
Overview
Interleukin-2 tyrosine kinase (Itk) is a T cell-specific kinase required for a proper immune response following T cell receptor engagement. In addition to the kinase domain, Itk is composed of several noncatalytic regulatory domains, including a Src homology 2 (SH2) domain that contains a conformationally heterogeneous Pro residue. Cis-trans isomerization of a single prolyl imide bond within the SH2 domain mediates conformer-specific ligand recognition that may have functional implications in T cell signaling. To better understand the mechanism by which a proline switch regulates ligand binding, we have used NMR spectroscopy to determine two structures of Itk SH2 corresponding to the cis and trans imide bond-containing conformers. The structures indicate that the heterogeneous Pro residue acts as a hinge that modulates ligand recognition by controlling the relative orientation of protein-binding surfaces.
About this Structure
1LUM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain., Mallis RJ, Brazin KN, Fulton DB, Andreotti AH, Nat Struct Biol. 2002 Dec;9(12):900-5. PMID:12402030 Page seeded by OCA on Sat May 3 00:18:30 2008
