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==Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor [PSI-NYSGRC-006220]==
==Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor [PSI-NYSGRC-006220]==
<StructureSection load='4nof' size='340' side='right' caption='[[4nof]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='4nof' size='340' side='right'caption='[[4nof]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NOF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nob|4nob]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nof OCA], [https://pdbe.org/4nof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nof RCSB], [https://www.ebi.ac.uk/pdbsum/4nof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nof ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pigr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nof OCA], [http://pdbe.org/4nof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nof RCSB], [http://www.ebi.ac.uk/pdbsum/4nof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nof ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PIGR_MOUSE PIGR_MOUSE]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).  
[https://www.uniprot.org/uniprot/PIGR_MOUSE PIGR_MOUSE] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Ahmed, M]]
[[Category: Mus musculus]]
[[Category: Almo, S C]]
[[Category: Ahmed M]]
[[Category: Attonito, J]]
[[Category: Almo SC]]
[[Category: Banu, R]]
[[Category: Attonito J]]
[[Category: Bhosle, R]]
[[Category: Banu R]]
[[Category: Calarese, D A]]
[[Category: Bhosle R]]
[[Category: Casadevall, A]]
[[Category: Calarese DA]]
[[Category: Celikgil, A]]
[[Category: Casadevall A]]
[[Category: Chamala, S]]
[[Category: Celikgil A]]
[[Category: Chan, M K]]
[[Category: Chamala S]]
[[Category: Chowdhury, S]]
[[Category: Chan MK]]
[[Category: Fiser, A]]
[[Category: Chowdhury S]]
[[Category: Garforth, S J]]
[[Category: Fiser A]]
[[Category: Glenn, A S]]
[[Category: Garforth SJ]]
[[Category: Hillerich, B]]
[[Category: Glenn AS]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
[[Category: Hillerich B]]
[[Category: Khafizov, K]]
[[Category: Khafizov K]]
[[Category: Kumar, P R]]
[[Category: Kumar PR]]
[[Category: Love, J D]]
[[Category: Love JD]]
[[Category: Structural genomic]]
[[Category: Patel H]]
[[Category: Patel, H]]
[[Category: Patel R]]
[[Category: Patel, R]]
[[Category: Sampathkumar P]]
[[Category: Sampathkumar, P]]
[[Category: Seidel RD]]
[[Category: Seidel, R D]]
[[Category: Smith B]]
[[Category: Smith, B]]
[[Category: Stead M]]
[[Category: Stead, M]]
[[Category: Ifn]]
[[Category: Ig domain]]
[[Category: Immune function network]]
[[Category: Immune system]]
[[Category: Nysgrc]]
[[Category: Ortholog]]
[[Category: Polymeric immunoglobulin receptor]]
[[Category: Psi-biology]]

Revision as of 08:38, 11 January 2023

Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor [PSI-NYSGRC-006220]

4nof, resolution 1.65Å

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