4i3n: Difference between revisions

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==Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant D61N==
==Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant D61N==
<StructureSection load='4i3n' size='340' side='right' caption='[[4i3n]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='4i3n' size='340' side='right'caption='[[4i3n]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4i3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I3N FirstGlance]. <br>
<table><tr><td colspan='2'>[[4i3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I3N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xoa|2xoa]], [[4i0y|4i0y]], [[4i1e|4i1e]], [[4i2s|4i2s]], [[4i37|4i37]], [[4i6i|4i6i]], [[4i7i|4i7i]], [[4i8m|4i8m]], [[4i96|4i96]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i3n OCA], [https://pdbe.org/4i3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i3n RCSB], [https://www.ebi.ac.uk/pdbsum/4i3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i3n ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i3n OCA], [http://pdbe.org/4i3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i3n RCSB], [http://www.ebi.ac.uk/pdbsum/4i3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i3n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Ryanodine receptor|Ryanodine receptor]]
*[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: European rabbit]]
[[Category: Large Structures]]
[[Category: Kimlicka, L]]
[[Category: Oryctolagus cuniculus]]
[[Category: Petegem, F Van]]
[[Category: Kimlicka L]]
[[Category: Calcium channel]]
[[Category: Van Petegem F]]
[[Category: Metal transport]]
[[Category: Sr/er membrane]]
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