4imo: Difference between revisions

<StructureSection load='4imo' size='340' side='right'caption='[[4imo]], [[Resolution|resolution]] 1.88&Aring;' scene=''>

<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMO FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [https://pdbe.org/4imo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [https://www.ebi.ac.uk/pdbsum/4imo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imo ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>  

*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]

*[[Prostaglandin D synthase|Prostaglandin D synthase]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chen D]]

[[Category: Lim SM]]

[[Category: Nordlund P]]

[[Category: Nyman T]]

[[Category: Pervushin K]]

[[Category: Roos A]]

[[Category: Teo H]]

[[Category: Tresaugues L]]