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==Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with SAH==
==Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with SAH==
<StructureSection load='4gbe' size='340' side='right' caption='[[4gbe]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
<StructureSection load='4gbe' size='340' side='right'caption='[[4gbe]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gbe]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GBE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gbe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GBE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3387, dam, JW3350 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbe OCA], [https://pdbe.org/4gbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gbe RCSB], [https://www.ebi.ac.uk/pdbsum/4gbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbe ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Site-specific_DNA-methyltransferase_(adenine-specific) Site-specific DNA-methyltransferase (adenine-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.72 2.1.1.72] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbe OCA], [http://pdbe.org/4gbe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gbe RCSB], [http://www.ebi.ac.uk/pdbsum/4gbe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DMA_ECOLI DMA_ECOLI]] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication.  
[https://www.uniprot.org/uniprot/DMA_ECOLI DMA_ECOLI] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication.


==See Also==
==See Also==
*[[DNA adenine methylase|DNA adenine methylase]]
*[[DNA adenine methylase|DNA adenine methylase]]
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Harmer, J E]]
[[Category: Large Structures]]
[[Category: Roach, P L]]
[[Category: Harmer JE]]
[[Category: Methylation]]
[[Category: Roach PL]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4gbe"