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==Structure of LD transpeptidase LdtMt1 in complex with imipenem==
==Structure of LD transpeptidase LdtMt1 in complex with imipenem==
<StructureSection load='4jmx' size='340' side='right' caption='[[4jmx]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='4jmx' size='340' side='right'caption='[[4jmx]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jmx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JMX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jmx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JMX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM2:(5R)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-[(2-{[(E)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IM2:(5R)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-[(2-{[(E)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jmn|4jmn]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmx OCA], [https://pdbe.org/4jmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jmx RCSB], [https://www.ebi.ac.uk/pdbsum/4jmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmx ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ldtA, Rv0116c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmx OCA], [http://pdbe.org/4jmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jmx RCSB], [http://www.ebi.ac.uk/pdbsum/4jmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LDT1_MYCTU LDT1_MYCTU] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is thought to play a role in adaptation to the nonreplicative state of M.tuberculosis.<ref>PMID:18408028</ref> <ref>PMID:24041897</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Berisio, R]]
[[Category: Large Structures]]
[[Category: Capparelli, R]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Correale, S]]
[[Category: Berisio R]]
[[Category: Pedone, E]]
[[Category: Capparelli R]]
[[Category: Ruggiero, A]]
[[Category: Correale S]]
[[Category: Ig-like and beta barrel]]
[[Category: Pedone E]]
[[Category: Transferase]]
[[Category: Ruggiero A]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4jmx"