1mhe: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1mhe.jpg|left|200px]] | [[Image:1mhe.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1mhe", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
| | {{STRUCTURE_1mhe| PDB=1mhe | SCENE= }} | ||
| | |||
}} | |||
'''THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E''' | '''THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E''' | ||
| Line 34: | Line 31: | ||
[[Category: Tormo, J.]] | [[Category: Tormo, J.]] | ||
[[Category: Willcox, B E.]] | [[Category: Willcox, B E.]] | ||
[[Category: | [[Category: Beta 2 microglobulin]] | ||
[[Category: | [[Category: Class ib mhc]] | ||
[[Category: | [[Category: Hla]] | ||
[[Category: | [[Category: Hla e]] | ||
[[Category: | [[Category: Hla-e]] | ||
[[Category: | [[Category: Leader peptide]] | ||
[[Category: | [[Category: Major histocompatibility complex]] | ||
[[Category: | [[Category: Mhc]] | ||
[[Category: | [[Category: Non-classical mhc]] | ||
[[Category: | [[Category: Peptide]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:01:53 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 22:01, 2 May 2008
THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E
Overview
The crystal structure of the nonclassical human class lb MHC molecule HLA-E has been determined in complex with a prototypic ligand, the nonamer peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of the human MHC class la leader sequence. The mode of peptide binding retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific binding to a tightly defined set of almost identical hydrophobic peptides from the highly conserved class l leader sequences. These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells.
About this Structure
1MHE is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E., O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY, Mol Cell. 1998 Mar;1(4):531-41. PMID:9660937 Page seeded by OCA on Sat May 3 01:01:53 2008
