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==Crystal structure of the C-terminal regulatory domain of murine GCN2==
==Crystal structure of the C-terminal regulatory domain of murine GCN2==
<StructureSection load='4otn' size='340' side='right' caption='[[4otn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4otn' size='340' side='right'caption='[[4otn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4otn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4otn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OTN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4otm|4otm]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4otn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4otn OCA], [https://pdbe.org/4otn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4otn RCSB], [https://www.ebi.ac.uk/pdbsum/4otn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4otn ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Eif2ak4, Gcn2, Kiaa1338 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4otn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4otn OCA], [http://pdbe.org/4otn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4otn RCSB], [http://www.ebi.ac.uk/pdbsum/4otn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4otn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/E2AK4_MOUSE E2AK4_MOUSE]] Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.  
[https://www.uniprot.org/uniprot/E2AK4_MOUSE E2AK4_MOUSE] Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4otn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4otn" style="background-color:#fffaf0;"></div>
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Mus musculus]]
[[Category: Georgiadis, M M]]
[[Category: Georgiadis MM]]
[[Category: He, H]]
[[Category: He H]]
[[Category: 4-stranded beta sheet 3 helix bundle]]
[[Category: C-terminal regulatory domain]]
[[Category: Gcn2]]
[[Category: Regulatory domain of eif2 stress kinase]]
[[Category: Transferase]]
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