4jar: Difference between revisions

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==Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES==
==Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES==
<StructureSection load='4jar' size='340' side='right' caption='[[4jar]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='4jar' size='340' side='right'caption='[[4jar]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jar]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JAR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jar]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JAR FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jao|4jao]], [[4jap|4jap]], [[4jaq|4jaq]], [[4jat|4jat]], [[4jd3|4jd3]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jar OCA], [https://pdbe.org/4jar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jar RCSB], [https://www.ebi.ac.uk/pdbsum/4jar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jar ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pks11, Rv1665, MT1705 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jar OCA], [http://pdbe.org/4jar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jar RCSB], [http://www.ebi.ac.uk/pdbsum/4jar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jar ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PKS11_MYCTU PKS11_MYCTU]] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.  
[https://www.uniprot.org/uniprot/PKS11_MYCTU PKS11_MYCTU] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gokulan, K]]
[[Category: Large Structures]]
[[Category: Sacchettini, J C]]
[[Category: Mycobacterium tuberculosis]]
[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project]]
[[Category: Gokulan K]]
[[Category: Alkylpyrone synthesis]]
[[Category: Sacchettini JC]]
[[Category: Enzyme function initiative]]
[[Category: Ketosynthase enzyme]]
[[Category: Lipid biosynthesis]]
[[Category: Structural genomic]]
[[Category: Transferase]]