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==Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)==
==Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)==
<StructureSection load='4ka4' size='340' side='right' caption='[[4ka4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4ka4' size='340' side='right'caption='[[4ka4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ka4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KA4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ka4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KA4 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eyi|3eyi]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ka4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ka4 OCA], [https://pdbe.org/4ka4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ka4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ka4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ka4 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBP1, C20orf183, DLM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ka4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ka4 OCA], [http://pdbe.org/4ka4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ka4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ka4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ka4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).  
[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Athanasiadis, A]]
[[Category: Large Structures]]
[[Category: Rosa, M de]]
[[Category: Athanasiadis A]]
[[Category: Sanctis, D De]]
[[Category: De Sanctis D]]
[[Category: Dna binding protein-dna complex]]
[[Category: De Rosa M]]
[[Category: Dna sensor]]
[[Category: Whth]]
[[Category: Z-dna binding]]
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