2wmn: Difference between revisions

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==~~STRUCTURE OF THE COMPLEX BETWEEN~~ DOCK9 ~~AND CDC42~~-GDP.==

==Structure of the complex between DOCK9 and Cdc42-GDP.==

== Structural highlights ==

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</table>

== Function ==

[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>

[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

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==See Also==

*[[Dedicator of cytokinesis protein|Dedicator of cytokinesis protein]]

*[[GTP-binding protein|GTP-binding protein]]

== References ==

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[[Category: Roe, S M]]

[[Category: Yang, J]]

[[Category: Alternative splicing]]

[[Category: Cdc42]]

[[Category: Cell cycle]]

[[Category: Cell membrane]]

[[Category: Coiled coil]]

[[Category: Dock9]]

[[Category: Gef]]

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[[Category: Nucleotide-binding]]

[[Category: Phosphoprotein]]

[[Category: Polymorphism]]

[[Category: Prenylation]]

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@@ Line 1: / Line 1: @@
-==STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.==
+==Structure of the complex between DOCK9 and Cdc42-GDP.==
 <StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
 == Structural highlights ==
@@ Line 9: / Line 9: @@
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>  [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
+[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 31: / Line 31: @@
 ==See Also==
+*[[Dedicator of cytokinesis protein|Dedicator of cytokinesis protein]]
 *[[GTP-binding protein|GTP-binding protein]]
 == References ==
@@ Line 40: / Line 41: @@
 [[Category: Roe, S M]]
 [[Category: Yang, J]]
+[[Category: Alternative splicing]]
 [[Category: Cdc42]]
 [[Category: Cell cycle]]
 [[Category: Cell membrane]]
+[[Category: Coiled coil]]
 [[Category: Dock9]]
 [[Category: Gef]]
@@ Line 53: / Line 56: @@
 [[Category: Nucleotide-binding]]
 [[Category: Phosphoprotein]]
+[[Category: Polymorphism]]
 [[Category: Prenylation]]