4m6r: Difference between revisions

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==Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme==
==Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme==
<StructureSection load='4m6r' size='340' side='right' caption='[[4m6r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4m6r' size='340' side='right'caption='[[4m6r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m6r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M6R FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m6r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APIP, CGI-29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6r OCA], [https://pdbe.org/4m6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6r RCSB], [https://www.ebi.ac.uk/pdbsum/4m6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6r ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioribulose_1-phosphate_dehydratase Methylthioribulose 1-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.109 4.2.1.109] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6r OCA], [http://pdbe.org/4m6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m6r RCSB], [http://www.ebi.ac.uk/pdbsum/4m6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MTNB_HUMAN MTNB_HUMAN]] Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.<ref>PMID:15262985</ref> <ref>PMID:23285211</ref> <ref>PMID:22837397</ref>
[https://www.uniprot.org/uniprot/MTNB_HUMAN MTNB_HUMAN] Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.<ref>PMID:15262985</ref> <ref>PMID:23285211</ref> <ref>PMID:22837397</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Methylthioribulose 1-phosphate dehydratase]]
[[Category: Large Structures]]
[[Category: Ashida, H]]
[[Category: Ashida H]]
[[Category: Chun, K H]]
[[Category: Chun KH]]
[[Category: Hah, S S]]
[[Category: Hah SS]]
[[Category: Hong, S H]]
[[Category: Hong SH]]
[[Category: Jung, Y K]]
[[Category: Jung YK]]
[[Category: Kang, W]]
[[Category: Kang W]]
[[Category: Kim, H C]]
[[Category: Kim HC]]
[[Category: Kim, N Y]]
[[Category: Kim NY]]
[[Category: Kim, T Y]]
[[Category: Kim TY]]
[[Category: Le, L T.M]]
[[Category: Le LTM]]
[[Category: Lee, H M]]
[[Category: Lee HM]]
[[Category: Lim, B]]
[[Category: Lim B]]
[[Category: Lim, Y C]]
[[Category: Lim YC]]
[[Category: Yang, J K]]
[[Category: Yang JK]]
[[Category: Yokota, A]]
[[Category: Yokota A]]
[[Category: Apip]]
[[Category: Class ii aldolase family]]
[[Category: Dehydratase]]
[[Category: Lyase]]
[[Category: Mtnb]]
Retrieved from "https://proteopedia.org/4m6r"