4lku

Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance

spinqualitylabelsall models 4lku, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4lku is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [C9QXJ2_ECOD1] Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity).[SAAS:SAAS001185_004_016395][HAMAP-Rule:MF_00115] Publication Abstract from PubMed The crystal structure of the cytoplasmic domain (CTD) from the mechanosensitive channel of large conductance (MscL) in E. coli has been determined at 1.45 A resolution. This domain forms a pentameric coiled coil similar to that observed in the structure of MscL from M. tuberculosis and also found in the Cartilage Oligomeric Matrix Protein (COMPcc). It contains canonical hydrophobic and atypical ionic interactions compared to previously characterized coiled coil structures. Thermodynamic analysis indicates that while the free EcMscL-CTD is less stable than other coiled coils, it is likely to remain folded in context of the full-length channel. Structure and stability of the C-terminal helical bundle of the E. coli mechanosensitive channel of large conductance.,Walton TA, Rees DC Protein Sci. 2013 Aug 29. doi: 10.1002/pro.2360. PMID:24038743 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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