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==X-ray Crystal Structure of Human TBC1D4 (AS160) RabGAP domain==
==X-ray Crystal Structure of Human TBC1D4 (AS160) RabGAP domain==
<StructureSection load='3qyb' size='340' side='right' caption='[[3qyb]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='3qyb' size='340' side='right'caption='[[3qyb]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qyb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QYB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qyb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYB FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qye|3qye]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qye|3qye]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBC1D4, AS160, KIAA0603 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBC1D4, AS160, KIAA0603 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyb OCA], [http://pdbe.org/3qyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qyb RCSB], [http://www.ebi.ac.uk/pdbsum/3qyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyb OCA], [https://pdbe.org/3qyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyb RCSB], [https://www.ebi.ac.uk/pdbsum/3qyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TBCD4_HUMAN TBCD4_HUMAN]] May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.<ref>PMID:15971998</ref> <ref>PMID:18771725</ref> <ref>PMID:22908308</ref>   
[[https://www.uniprot.org/uniprot/TBCD4_HUMAN TBCD4_HUMAN]] May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.<ref>PMID:15971998</ref> <ref>PMID:18771725</ref> <ref>PMID:22908308</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Park, S Y]]
[[Category: Park, S Y]]
[[Category: Shoelson, S E]]
[[Category: Shoelson, S E]]
Retrieved from "https://proteopedia.org/3qyb"