4kw3: Difference between revisions
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==Crystal structure of the non-structural protein 1 N-terminal origin-recognition/nickase domain from the emerging human bocavirus== | ==Crystal structure of the non-structural protein 1 N-terminal origin-recognition/nickase domain from the emerging human bocavirus== | ||
<StructureSection load='4kw3' size='340' side='right' caption='[[4kw3]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='4kw3' size='340' side='right'caption='[[4kw3]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4kw3]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4kw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_bocavirus Human bocavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KW3 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kw3 OCA], [https://pdbe.org/4kw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4kw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kw3 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NS1_HBOC1 NS1_HBOC1] Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication. Also plays a role in viral packaging and transactivation of several promoters. Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR). Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis. The helicase activity unwinds DNA in a 3'-5' direction on the longer strand. Participates in the transcriptional regulation of several promoters.[UniProtKB:P03134] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human bocavirus]] | [[Category: Human bocavirus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Tang L]] | ||
[[Category: | [[Category: Tewary SK]] | ||
[[Category: | [[Category: Zhao H]] | ||
