4h2o: Difference between revisions

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==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1248==
==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1248==
<StructureSection load='4h2o' size='340' side='right' caption='[[4h2o]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
<StructureSection load='4h2o' size='340' side='right'caption='[[4h2o]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H2O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H2O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0YW:2-{[3-(DECYLOXY)BENZOYL]AMINO}-5-NITROBENZOIC+ACID'>0YW</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0YW:2-{[3-(DECYLOXY)BENZOYL]AMINO}-5-NITROBENZOIC+ACID'>0YW</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h2j|4h2j]], [[4h2m|4h2m]], [[4h38|4h38]], [[4h3a|4h3a]], [[4h3c|4h3c]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2o OCA], [https://pdbe.org/4h2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h2o RCSB], [https://www.ebi.ac.uk/pdbsum/4h2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uppS, ispU, rth, yaeS, b0174, JW0169 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ditrans,polycis-undecaprenyl-diphosphate_synthase_((2E,6E)-farnesyl-_diphosphate_specific) Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2o OCA], [http://pdbe.org/4h2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h2o RCSB], [http://www.ebi.ac.uk/pdbsum/4h2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI]] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>
[https://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Oldfield, E]]
[[Category: Large Structures]]
[[Category: Zhu, W]]
[[Category: Oldfield E]]
[[Category: Alpha-helix]]
[[Category: Zhu W]]
[[Category: Cell wall biosynthesis]]
[[Category: Farnesyl diphosphate binding]]
[[Category: Isopentenyl diphosphate binding]]
[[Category: Prenyl transferase]]
[[Category: Prenyl transferase inhibitor complex]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4h2o"