3v97: Difference between revisions

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==Crystal structure of bifunctional methyltransferase YcbY (RlmLK) from Escherichia coli, SAH binding==
==Crystal structure of bifunctional methyltransferase YcbY (RlmLK) from Escherichia coli, SAH binding==
<StructureSection load='3v97' size='340' side='right' caption='[[3v97]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3v97' size='340' side='right'caption='[[3v97]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3v97]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V97 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3v97]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V97 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OSU:N-OCTANOYLSUCROSE'>OSU</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v8v|3v8v]]</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRV:'>TRV</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rlmL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v8v|3v8v]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/23S_rRNA_(guanine(2445)-N(2))-methyltransferase 23S rRNA (guanine(2445)-N(2))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.173 2.1.1.173] </span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rlmL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v97 OCA], [http://pdbe.org/3v97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v97 RCSB], [http://www.ebi.ac.uk/pdbsum/3v97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v97 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/23S_rRNA_(guanine(2445)-N(2))-methyltransferase 23S rRNA (guanine(2445)-N(2))-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.173 2.1.1.173] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v97 OCA], [https://pdbe.org/3v97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v97 RCSB], [https://www.ebi.ac.uk/pdbsum/3v97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v97 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RLMKL_ECOLI RLMKL_ECOLI]] Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits.<ref>PMID:17010378</ref> <ref>PMID:22210896</ref> <ref>PMID:22362734</ref>   
[[https://www.uniprot.org/uniprot/RLMKL_ECOLI RLMKL_ECOLI]] Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits.<ref>PMID:17010378</ref> <ref>PMID:22210896</ref> <ref>PMID:22362734</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Su, X D]]
[[Category: Su, X D]]
[[Category: Wang, K T]]
[[Category: Wang, K T]]
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