1bsx: Difference between revisions
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==Overview== | ==Overview== | ||
Combinatorial regulation of transcription implies flexible yet precise, assembly of multiprotein regulatory complexes in response to signals., Biochemical and crystallographic analyses revealed that hormone binding, leads to the formation of a hydrophobic groove within the ligand binding, domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL, motif-containing alpha-helix from GRIP1, a coactivator. Residues, immediately adjacent to the motif modulate the affinity of the, interaction; the motif and the adjacent sequences are employed to, different extents in binding to different receptors. Such interactions of, amphipathic alpha-helices with hydrophobic grooves define protein, interfaces in other regulatory complexes as well. We suggest that these, common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity. | Combinatorial regulation of transcription implies flexible yet precise, assembly of multiprotein regulatory complexes in response to signals., Biochemical and crystallographic analyses revealed that hormone binding, leads to the formation of a hydrophobic groove within the ligand binding, domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL, motif-containing alpha-helix from GRIP1, a coactivator. Residues, immediately adjacent to the motif modulate the affinity of the, interaction; the motif and the adjacent sequences are employed to, different extents in binding to different receptors. Such interactions of, amphipathic alpha-helices with hydrophobic grooves define protein, interfaces in other regulatory complexes as well. We suggest that these, common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity. | ||
==Disease== | |||
Known diseases associated with this structure: Thyroid hormone resistance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190160 190160]], Thyroid hormone resistance, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190160 190160]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: specificity interaction site]] | [[Category: specificity interaction site]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:14:05 2007'' | ||
