Rhomboid protease: Difference between revisions
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<StructureSection load=' | <StructureSection load='2xow' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin (PDB entry [[2xow]])' scene=''> | ||
== Function == | == Function == | ||
'''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected | '''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | ||
== Structural highlights == | |||
The inhibitor isocoumarin binds to the GlpG catalytic residues Ser and His<ref>PMID:20890268</ref>. | |||
</StructureSection> | </StructureSection> | ||
