1n96: Difference between revisions
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{{STRUCTURE_1n96| PDB=1n96 | SCENE= }} | |||
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'''DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)''' | '''DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA]. | |||
==Reference== | ==Reference== | ||
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad., Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C, J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12733903 12733903] | Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad., Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C, J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12733903 12733903] | ||
[[Category: Escaja, N.]] | [[Category: Escaja, N.]] | ||
[[Category: Gelpi, J L.]] | [[Category: Gelpi, J L.]] | ||
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[[Category: Pedroso, E.]] | [[Category: Pedroso, E.]] | ||
[[Category: Rico, M.]] | [[Category: Rico, M.]] | ||
[[Category: | [[Category: Bi-loop]] | ||
[[Category: | [[Category: Four-stranded dna]] | ||
[[Category: | [[Category: Quadruplex]] | ||
[[Category: | [[Category: Unusual dna]] | ||
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Revision as of 23:15, 2 May 2008
DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)
Overview
The solution structure of a cyclic oligonucleotide d<pCGCTCATT> has been determined by two-dimensional NMR spectroscopy and restrained molecular dynamics. Under the appropriate experimental conditions, this molecule self-associates, forming a symmetric dimer stabilized by four intermolecular Watson-Crick base pairs. The resulting four-stranded structure consists of two G:C:A:T tetrads, formed by facing the minor groove side of the Watson-Crick base-pairs. Most probably, the association of the base-pairs is stabilized by coordinating a Na(+) cation. This is the first time that this novel G:C:A:T tetrad has been found in an oligonucleotide structure. This observation increases considerably the number of sequences that may adopt a four-stranded architecture. Overall, the three-dimensional structure is similar to those observed previously in other quadruplexes formed by minor groove alignment of Watson-Crick base pairs. This resemblance strongly suggests that we may be observing a general motif for DNA-DNA recognition.
About this Structure
Full crystallographic information is available from OCA.
Reference
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad., Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C, J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:12733903 Page seeded by OCA on Sat May 3 02:15:06 2008
