5khx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5khx is ~~ON HOLD until Paper Publication~~

==Crystal structure of JAK1 in complex with PF-4950736==

~~Authors~~: ~~Han~~, S., ~~Caspers~~, N.L.

== Structural highlights ==

<table><tr><td colspan='2'>[[5khx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHX OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KHX FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~JAK1~~ in ~~complex with PF~~-~~4950736~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=6TE:~{N}-[3-[METHYL(7~{H}-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]CYCLOBUTYL]METHANESULFONAMIDE'>6TE</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>

[[Category: Caspers, N.L]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5khx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khx OCA], [http://pdbe.org/5khx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khx RCSB], [http://www.ebi.ac.uk/pdbsum/5khx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khx ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

__TOC__

</StructureSection>

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Caspers, N L]]

[[Category: Han, S]]

[[Category: Complex]]

[[Category: Inhibitor]]

[[Category: Jak1]]

[[Category: Kinase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5khx is ON HOLD  until Paper Publication
+==Crystal structure of JAK1 in complex with PF-4950736==
+<StructureSection load='5khx' size='340' side='right' caption='[[5khx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Han, S., Caspers, N.L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5khx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KHX FirstGlance]. <br>
-Description: Crystal structure of JAK1 in complex with PF-4950736
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6TE:~{N}-[3-[METHYL(7~{H}-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]CYCLOBUTYL]METHANESULFONAMIDE'>6TE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-[[Category: Caspers, N.L]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5khx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khx OCA], [http://pdbe.org/5khx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khx RCSB], [http://www.ebi.ac.uk/pdbsum/5khx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
+__TOC__
+</StructureSection>
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Caspers, N L]]
 [[Category: Han, S]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Jak1]]
+[[Category: Kinase]]
+[[Category: Transferase-transferase inhibitor complex]]