5l19: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5l19 is ~~ON HOLD until Paper Publication~~

==Crystal Structure of a human FasL mutant==

~~Authors~~: ~~Liu~~, W., ~~Bonanno~~, J.B., ~~Almo~~, S.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[5l19]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L19 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L19 FirstGlance].

~~Description~~: ~~Crystal Structure of a human FasL mutant~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4msv|4msv]]</td></tr>

[[Category: Almo, S.C]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l19 OCA], [http://pdbe.org/5l19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l19 RCSB], [http://www.ebi.ac.uk/pdbsum/5l19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l19 ProSAT]</td></tr>

[[Category: Bonanno, J.B]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Almo, S C]]

[[Category: Bonanno, J B]]

[[Category: Liu, W]]

[[Category: Apoptosis]]

[[Category: Cd95l]]

[[Category: Fasl]]

[[Category: Tnf ligand]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5l19 is ON HOLD  until Paper Publication
+==Crystal Structure of a human FasL mutant==
+<StructureSection load='5l19' size='340' side='right' caption='[[5l19]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Liu, W., Bonanno, J.B., Almo, S.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5l19]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L19 FirstGlance]. <br>
-Description: Crystal Structure of a human FasL mutant
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4msv|4msv]]</td></tr>
-[[Category: Almo, S.C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l19 OCA], [http://pdbe.org/5l19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l19 RCSB], [http://www.ebi.ac.uk/pdbsum/5l19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l19 ProSAT]</span></td></tr>
-[[Category: Bonanno, J.B]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref>   The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Almo, S C]]
+[[Category: Bonanno, J B]]
 [[Category: Liu, W]]
+[[Category: Apoptosis]]
+[[Category: Cd95l]]
+[[Category: Fasl]]
+[[Category: Tnf ligand]]