5l36: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5l36" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of a human FasL mutant in complex with human DcR3== | |||
<StructureSection load='5l36' size='340' side='right' caption='[[5l36]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l36]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L36 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l19|5l19]], [[4msv|4msv]]</td></tr> | ||
[[Category: Almo, S | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l36 OCA], [http://pdbe.org/5l36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l36 RCSB], [http://www.ebi.ac.uk/pdbsum/5l36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l36 ProSAT]</span></td></tr> | ||
[[Category: Bonanno, J | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Almo, S C]] | |||
[[Category: Bonanno, J B]] | |||
[[Category: Liu, W]] | [[Category: Liu, W]] | ||
[[Category: Apoptosis]] | |||
[[Category: Cd95l]] | |||
[[Category: Dcr3]] | |||
[[Category: Decoy receptor]] | |||
[[Category: Fasl]] | |||
[[Category: Tnf ligand and receptor]] | |||
Revision as of 21:14, 10 September 2016
Crystal Structure of a human FasL mutant in complex with human DcR3
| ||||||||||||
