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==2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphohydrolase from Bacteroides thetaiotaomicron in complex with transition state mimic==
==2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphohydrolase from Bacteroides thetaiotaomicron in complex with transition state mimic==
<StructureSection load='4hgo' size='340' side='right' caption='[[4hgo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4hgo' size='340' side='right'caption='[[4hgo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hgo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGO FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hgo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KDN:3-DEOXY-D-GLYCERO-BETA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>KDN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDN:3-DEOXY-D-GLYCERO-BETA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>KDN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e8m|3e8m]], [[4hgn|4hgn]], [[4hgp|4hgp]], [[4hgq|4hgq]], [[4hgr|4hgr]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgo OCA], [https://pdbe.org/4hgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgo RCSB], [https://www.ebi.ac.uk/pdbsum/4hgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgo ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BT_1713 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226186 BACTN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgo OCA], [http://pdbe.org/4hgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgo RCSB], [http://www.ebi.ac.uk/pdbsum/4hgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDGGP_BACTN KDGGP_BACTN] Involved in the biosynthesis of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid used in cell-wall polysaccharides (PubMed:18804026). Catalyzes the hydrolysis of 2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid (KDN-9-P) to yield 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:18804026, PubMed:18986982, PubMed:23848398). Also able to hydrolyze N-acetylneuraminate-9-phosphate (Neu5NAc-9-P), 2-keto-3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P), phosphoenolpyruvate (PEP), gluconate 6-phosphate, tyrosine phosphate ester and glucose-6-P as substrate (PubMed:18804026, PubMed:18986982, PubMed:23848398).<ref>PMID:18804026</ref> <ref>PMID:18986982</ref> <ref>PMID:23848398</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bactn]]
[[Category: Bacteroides thetaiotaomicron VPI-5482]]
[[Category: Allen, K N]]
[[Category: Large Structures]]
[[Category: Daughtry, K D]]
[[Category: Allen KN]]
[[Category: Hydrolase]]
[[Category: Daughtry KD]]
[[Category: Phosphohydroylase]]
[[Category: Rossmann fold]]
[[Category: Transferase]]
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