4m91: Difference between revisions

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==crystal structure of hN33/Tusc3-peptide 1==
==crystal structure of hN33/Tusc3-peptide 1==
<StructureSection load='4m91' size='340' side='right' caption='[[4m91]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='4m91' size='340' side='right'caption='[[4m91]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m91]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M91 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m91]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M91 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m8g|4m8g]], [[4m90|4m90]], [[4m92|4m92]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m91 OCA], [https://pdbe.org/4m91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m91 RCSB], [https://www.ebi.ac.uk/pdbsum/4m91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m91 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TUSC3, N33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CRBN, AD-006 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m91 OCA], [http://pdbe.org/4m91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m91 RCSB], [http://www.ebi.ac.uk/pdbsum/4m91 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m91 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TUSC3_HUMAN TUSC3_HUMAN]] Autosomal recessive nonsyndromic intellectual deficit. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN]] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/TUSC3_HUMAN TUSC3_HUMAN] Autosomal recessive nonsyndromic intellectual deficit. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TUSC3_HUMAN TUSC3_HUMAN]] Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.<ref>PMID:19717468</ref> [[http://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN]] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref> 
[https://www.uniprot.org/uniprot/TUSC3_HUMAN TUSC3_HUMAN] Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.<ref>PMID:19717468</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Aebi, M]]
[[Category: Large Structures]]
[[Category: Brozzo, M S]]
[[Category: Aebi M]]
[[Category: Glockshuber, R]]
[[Category: Brozzo MS]]
[[Category: Malojcic, G]]
[[Category: Glockshuber R]]
[[Category: Mohorko, E]]
[[Category: Malojcic G]]
[[Category: Owen, R L]]
[[Category: Mohorko E]]
[[Category: Endoplasmic reticulum]]
[[Category: Owen RL]]
[[Category: Formation of mixed disulfide]]
[[Category: Oxidoreductase]]
[[Category: Thioredoxin-like fold]]
Retrieved from "https://proteopedia.org/4m91"