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==Structure of the effector protein Tse1 from Pseudomonas aeruginosa==
==Structure of the effector protein Tse1 from Pseudomonas aeruginosa==
<StructureSection load='4fge' size='340' side='right' caption='[[4fge]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4fge' size='340' side='right'caption='[[4fge]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FGE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fge]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FGE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fgd|4fgd]], [[4fgi|4fgi]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fge OCA], [https://pdbe.org/4fge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fge RCSB], [https://www.ebi.ac.uk/pdbsum/4fge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fge ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1844 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fge OCA], [http://pdbe.org/4fge PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fge RCSB], [http://www.ebi.ac.uk/pdbsum/4fge PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fge ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSE1_PSEAE TSE1_PSEAE] Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria (PubMed:21776080, PubMed:22931054, PubMed:22813741, PubMed:22700987). To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin (PubMed:21776080, PubMed:22931054, PubMed:22700987).<ref>PMID:21776080</ref> <ref>PMID:22700987</ref> <ref>PMID:22813741</ref> <ref>PMID:22931054</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseae]]
[[Category: Large Structures]]
[[Category: Barends, T R.M]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Benz, J]]
[[Category: Barends TRM]]
[[Category: Meinhart, A]]
[[Category: Benz J]]
[[Category: Sendlmeier, C]]
[[Category: Meinhart A]]
[[Category: Cytosol]]
[[Category: Sendlmeier C]]
[[Category: Hydrolase]]
[[Category: N1pc/p60 superfamily]]
[[Category: Peptidoglycan hydrolase]]
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