4tw9: Difference between revisions
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==Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation== | ==Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation== | ||
<StructureSection load='4tw9' size='340' side='right' caption='[[4tw9]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='4tw9' size='340' side='right'caption='[[4tw9]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tw9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4tw9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=386:N-(2,2-DIFLUORO-5H-[1,3]DIOXOLO[4,5-F]BENZIMIDAZOL-6-YL)-2-{[2-(TRIFLUOROMETHOXY)BENZOYL]AMINO}-1,3-THIAZOLE-4-CARBOXAMIDE'>386</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HSJ:OCTYL+BETA-L-TALOPYRANOSIDE'>HSJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=386:N-(2,2-DIFLUORO-5H-[1,3]DIOXOLO[4,5-F]BENZIMIDAZOL-6-YL)-2-{[2-(TRIFLUOROMETHOXY)BENZOYL]AMINO}-1,3-THIAZOLE-4-CARBOXAMIDE'>386</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HSJ:OCTYL+BETA-L-TALOPYRANOSIDE'>HSJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSNK1D, HCKID ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw9 OCA], [http://pdbe.org/4tw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tw9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw9 OCA], [http://pdbe.org/4tw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tw9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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==See Also== | ==See Also== | ||
*[[Casein kinase|Casein kinase]] | *[[Casein kinase 3D structures|Casein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Alscher, V]] | [[Category: Alscher, V]] | ||
[[Category: Berg, S]] | [[Category: Berg, S]] | ||
