4otr: Difference between revisions
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==Crystal structure of BTK kinase domain complexed with 6-cyclopropyl-2-[3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3-pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one== | ==Crystal structure of BTK kinase domain complexed with 6-cyclopropyl-2-[3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3-pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one== | ||
<StructureSection load='4otr' size='340' side='right' caption='[[4otr]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='4otr' size='340' side='right'caption='[[4otr]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4otr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4otr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V3:6-CYCLOPROPYL-2-[3-(5-{[5-(4-ETHYLPIPERAZIN-1-YL)PYRIDIN-2-YL]AMINO}-1-METHYL-6-OXO-1,6-DIHYDROPYRIDIN-3-YL)-2-(HYDROXYMETHYL)PHENYL]-8-FLUOROISOQUINOLIN-1(2H)-ONE'>2V3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V3:6-CYCLOPROPYL-2-[3-(5-{[5-(4-ETHYLPIPERAZIN-1-YL)PYRIDIN-2-YL]AMINO}-1-METHYL-6-OXO-1,6-DIHYDROPYRIDIN-3-YL)-2-(HYDROXYMETHYL)PHENYL]-8-FLUOROISOQUINOLIN-1(2H)-ONE'>2V3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ot5|4ot5]], [[4ot6|4ot6]], [[4otq|4otq]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ot5|4ot5]], [[4ot6|4ot6]], [[4otq|4otq]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BTK, AGMX1, ATK, BPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4otr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4otr OCA], [http://pdbe.org/4otr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4otr RCSB], [http://www.ebi.ac.uk/pdbsum/4otr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4otr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4otr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4otr OCA], [http://pdbe.org/4otr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4otr RCSB], [http://www.ebi.ac.uk/pdbsum/4otr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4otr ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Kuglstatter, A]] | [[Category: Kuglstatter, A]] | ||
[[Category: Wong, A]] | [[Category: Wong, A]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
