4im8: Difference between revisions

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==low resolution crystal structure of mouse RAGE==
==low resolution crystal structure of mouse RAGE==
<StructureSection load='4im8' size='340' side='right' caption='[[4im8]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4im8' size='340' side='right'caption='[[4im8]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4im8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IM8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4im8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IM8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ager, RAGE, mCG_5497 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4im8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4im8 OCA], [https://pdbe.org/4im8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4im8 RCSB], [https://www.ebi.ac.uk/pdbsum/4im8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4im8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4im8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4im8 OCA], [http://pdbe.org/4im8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4im8 RCSB], [http://www.ebi.ac.uk/pdbsum/4im8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4im8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAGE_MOUSE RAGE_MOUSE] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation, amyloid accumulation, and impaired learning/memory in a mouse model of Alzheimer disease.<ref>PMID:10399917</ref> <ref>PMID:18539754</ref> <ref>PMID:19901339</ref> <ref>PMID:19906677</ref>  Is able to advanced glycosylation end product (AGE)-induce nuclear factor NF-kappa-B activation.<ref>PMID:16503878</ref>  Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro.<ref>PMID:24260107</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Chazin, W J]]
[[Category: Mus musculus]]
[[Category: Corbett, K D]]
[[Category: Chazin WJ]]
[[Category: Esko, J D]]
[[Category: Corbett KD]]
[[Category: Krahn, J M]]
[[Category: Esko JD]]
[[Category: Pedersen, L C]]
[[Category: Krahn JM]]
[[Category: Song, D]]
[[Category: Pedersen LC]]
[[Category: Xu, D]]
[[Category: Song D]]
[[Category: Young, J H]]
[[Category: Xu D]]
[[Category: Heparan sulfate]]
[[Category: Young JH]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4im8"