RING box protein: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='4f52' size='340' side='right' caption='Human RING finger protein 1 (green) complex with cullin-1 (grey), glomulin (magenta) and Zn+2 ions (grey) (PDB code [[4f52]])' scene=''> | <StructureSection load='4f52' size='340' side='right' caption='Human RING finger protein 1 (green) complex with cullin-1 (grey), glomulin (magenta) and Zn+2 ions (grey) (PDB code [[4f52]])' scene=''> | ||
'''RING box protein''' (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction. | '''RING box protein''' (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex<ref>PMID:21115485</ref>. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction. | ||
== Relevance == | == Relevance == | ||
Overexpression of RBX1 contributes to tumor progression and poor prognosis of non-muscle-invasive bladder transitional cell carcinoma<ref>PMID:23609182</ref>. RBX1 and RBX2 are overexpressed in multiple human cancer tissues and required for the growth and survival of cancer cells<ref>PMID:2102004</ref>. | |||
</StructureSection> | </StructureSection> | ||
