SAM-dependent methyltransferase

spinqualitylabelsall models SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate 3ou6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function SAM-dependent methyltransferase (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids. SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation. About 120 members of the SDM family have been identified. They differ in their substrate specificity and the atom targeted for methylation (N, O, C, S). For Chemotaxis receptor methyltransferase CheR see details in Molecular Playground/CheR.. SEE ALSO Chemotaxis protein. Structural highlights The core of the SDM fold contains alternating β strands and α helices. SDM active site is located between the 2 monomers.

3D structures of SAM-dependent methyltrasferase

Updated on 23-August-2016

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• SAM-dependent O-methyltransferase
  • Molecular Playground/CheR – TmSDM – Thermotoga maritima
    
  • Chemotaxis protein – SDM – Leptospira interrogans
    
  • 3r3h – SDM – Legionella pneumophila
    
  • 4qvk – PaSDM – Podospora anserina
    
  • 4ymg – PaSDM + SAM
    
  • 4ymh – PaSDM + SAH
    
  • 3ssm, 3sso – MgSDM + SAH – Micromonospora griseorubida
    
  • 3ssn – MgSDM + SAH + mycinamin
    
• SAM-dependent N-methyltransferase
  • 1vlm – TmSDM (mutant)
• SAM-dependent C-methyltransferase
  • 4m72 – ShSDM – Streptomyces hygroscopicus
    
  • 4m73, 4m74 – ShSDM (mutant)
    
  • 4kib – ShSDM + SAH + methylphenylpyruvate
    
  • 4kic – ShSDM + SAM + phenylpyruvate
    
  • 4kif, 4kig – ShSDM + phenylpyruvate
    
  • 4m6x, 4m6y, 4m71 – ShSDM (mutant) + SAH + methylphenylpyruvate
    
• SAM-dependent methyltransferase
  • 1wzn – SDM – Pyrococcus horikoshii
    
  • 2igt – SDM – Agrobacterium tumefaciens
    
  • 3cgg – CgSDM – Corynebacterium glutamicum
    
  • 3d2l - SDM – Exiguobacterium sibiricum
    
  • 3dh0 - SDM – Aquifex aeolicus
    
  • 3dp7 - SDM – Bacterioides vulgatus
    
  • 3ggd - SDM – Anabaena variabilis
    
  • 3sm3 - SDM (mutant) – Methanosarcina mazei
    
  • 3bkx – SDM – Lactobacillus casei
    
  • 3kr9 – SpSDM – Streptococcus pneumonia
    
• SAM-dependent methyltransferase complex with SAM/SAH
  • 3ku1 – SpSDM + SAM
    
  • 3lga – PaSDM + SAH – Pyrococcus abyssi
    
  • 3mb5 – PaSDM + SAM
    
  • 3ou2 – SlSDM + SAH – Streptomyces luridus
    
  • 3ou6 – SlSDM + SAM
    
  • 3ou7 – SlSDM + SAM + phosphonic acid derivative
    
  • 3h2b – CgSDM + pyrophosphate + SAH
    
  • 5bp7 – SlSDM + SAH – Geobacter sulfurreducens
    
  • 5epe – SDM + SAH – Thiobacillus denitrificans
    
  • 5bp9 – SDM + SAH – Bacterioides fragilis
    
  • 2ybo – PsaSDM + SAH – Pseudomonas aeruginosa
    
  • 2ybq – PsaSDM + SAH + uroporphyrinogen
    

• Chemotaxis receptor methyltransferase (CheR)
  • 1af7 – StCheR – Salmonella typhimurium
    
  • 1bc5 – StCheR + chemotaxis receptor peptide

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