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| *Di-or tripeptide:H+ symporter | | *Di-or tripeptide:H+ symporter |
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| **[[4ja4]], [[4xni]], [[4d2b]], [[4aps]] – StSymp – ''Streptococcus thermophilus''<BR /> | | **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]] – StSymp – ''Streptococcus thermophilus''<BR /> |
| **[[4d2d]] – StSymp + tripeptide<BR /> | | **[[4d2d]] – StSymp + tripeptide<BR /> |
| **[[4d2c]] – StSymp + dipeptide<BR /> | | **[[4d2c]], [[5d58]], [[5d59]] – StSymp + dipeptide<BR /> |
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| *Proton:oligopeptide symporter | | *Proton:oligopeptide symporter |
| Line 47: |
Line 47: |
| **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR /> | | **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR /> |
| **[[3dh4]] – VpSymp + galactose <BR /> | | **[[3dh4]] – VpSymp + galactose <BR /> |
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| | *Sodium/citrate symporter |
| | |
| | **[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR /> |
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| | *Purine/H+ symporter |
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| | **[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR /> |
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| }} | | }} |
| == References == | | == References == |
| <references/> | | <references/> |
| Function
Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction[1].
Disease
Mutations in sodium/iodide symporter cause iodide transport defects[2].
Structural highlights
Dipeptide:H symporter binds the dipeptide between its N- and C-terminal bundles[3].
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:https://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:https://dx.doi.org/10.15252/embr.201338403
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3D Structures of symporter
Updated on 06-September-2016
{"openlevels":0}
- D-xylose-proton symporter
- 4ja4, 4qiq – EcSymp – Escherichia coli
- 4ja3 – EcSymp (mutant)
- 4gby – EcSymp + xylose
- 4gbz, 4gc0 – EcSymp + glucose derivative
- Di-or tripeptide:H+ symporter
- Proton:oligopeptide symporter
- Sodium/bile acid symporter
- 4n7w – YfSymp – Yersinia frederiksenii
- 4n7x – YfSymp (mutant)
- L-fucose-proton symporter
- Sodium/glucose symporter
- 2xq2 – VpSymp (mutant) – Vibrio parahaemolyticus
- 3dh4 – VpSymp + galactose
- Sodium/citrate symporter
- 5a1s – Symp + citrate – Salmonella enterica
- Purine/H+ symporter
- 5i6c – Symp + xanthine – Aspergillus nidulans
References
