5gs9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5gs9 is ~~ON HOLD~~

==Crystal structure of CASTOR1-arginine==

~~Authors~~: ~~Zhang~~, T., ~~Ding~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5gs9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GS9 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of C1-R

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gs9 OCA], [http://pdbe.org/5gs9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gs9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gs9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gs9 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Ding, J]]

[[Category: Zhang, T]]

[[Category: ~~Ding, J~~]]

[[Category: Arginine binding]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5gs9 is ON HOLD
+==Crystal structure of CASTOR1-arginine==
+<StructureSection load='5gs9' size='340' side='right' caption='[[5gs9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Zhang, T., Ding, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5gs9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GS9 FirstGlance]. <br>
-Description: Crystal structure of C1-R
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gs9 OCA], [http://pdbe.org/5gs9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gs9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gs9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gs9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ding, J]]
 [[Category: Zhang, T]]
-[[Category: Ding, J]]
+[[Category: Arginine binding]]
+[[Category: Signaling protein]]