5lof: Difference between revisions

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'''Unreleased structure'''


The entry 5lof is ON HOLD
==Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1==
 
<StructureSection load='5lof' size='340' side='right' caption='[[5lof]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Dokurno, P., Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Csekei, M., Paczal, A., Szabo, Z., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G., Robertson, A., Surgenor, A., Chen, I., Matassova, N., Smith, J., Pedder, C., Graham, C., Geneste, O.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5lof]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOF FirstGlance]. <br>
Description: Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=70R:(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic+acid'>70R</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lof OCA], [http://pdbe.org/5lof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lof RCSB], [http://www.ebi.ac.uk/pdbsum/5lof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lof ProSAT]</span></td></tr>
[[Category: Paczal, A]]
</table>
[[Category: Pedder, C]]
== Function ==
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
__TOC__
</StructureSection>
[[Category: Balint, B]]
[[Category: Balint, B]]
[[Category: Sipos, S]]
[[Category: Blasko, G]]
[[Category: Chen, I]]
[[Category: Csekei, M]]
[[Category: Davidson, J]]
[[Category: Davidson, J]]
[[Category: Szabo, Z]]
[[Category: Blasko, G]]
[[Category: Szlavik, Z]]
[[Category: Proszenyak, A]]
[[Category: Murray, J]]
[[Category: Dokurno, P]]
[[Category: Dokurno, P]]
[[Category: Geneste, O]]
[[Category: Geneste, O]]
[[Category: Csekei, M]]
[[Category: Graham, C]]
[[Category: Surgenor, A]]
[[Category: Kotschy, A]]
[[Category: Chen, I]]
[[Category: Matassova, N]]
[[Category: Murray, J]]
[[Category: Ondi, L]]
[[Category: Paczal, A]]
[[Category: Pedder, C]]
[[Category: Proszenyak, A]]
[[Category: Radics, G]]
[[Category: Robertson, A]]
[[Category: Robertson, A]]
[[Category: Sipos, S]]
[[Category: Smith, J]]
[[Category: Smith, J]]
[[Category: Ondi, L]]
[[Category: Surgenor, A]]
[[Category: Matassova, N]]
[[Category: Szabo, Z]]
[[Category: Radics, G]]
[[Category: Szlavik, Z]]
[[Category: Kotschy, A]]
[[Category: Apoptosis-inhibitor complex]]
[[Category: Graham, C]]
[[Category: Mbp]]
[[Category: Mcl-1]]
[[Category: S s63845]]

Revision as of 18:48, 26 October 2016

Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1

5lof, resolution 2.20Å

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