5lqa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5lqa is ~~ON HOLD~~

==rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor==

~~Authors~~: ~~Ehler~~, A., ~~Ellermann~~, M., ~~Rudolph~~, M.G.

== Structural highlights ==

<table><tr><td colspan='2'>[[5lqa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LQA FirstGlance].

~~Description~~: ~~rat~~ catechol O-~~methyltransferase at high pH in complex with a bisubstrate inhibitor~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=619:N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ETHYLAMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>619</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqa OCA], [http://pdbe.org/5lqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqa RCSB], [http://www.ebi.ac.uk/pdbsum/5lqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqa ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

__TOC__

</StructureSection>

[[Category: Catechol O-methyltransferase]]

[[Category: Ehler, A]]

[[Category: Ellermann, M]]

[[Category: Rudolph, M.G]]

[[Category: Rudolph, M G]]

[[Category: Methyltransferase]]

[[Category: Neurotransmitter degradation]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lqa is ON HOLD
+==rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor==
+<StructureSection load='5lqa' size='340' side='right' caption='[[5lqa]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-Authors: Ehler, A., Ellermann, M., Rudolph, M.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lqa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LQA FirstGlance]. <br>
-Description: rat catechol O-methyltransferase at high pH in complex with a bisubstrate inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=619:N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ETHYLAMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>619</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqa OCA], [http://pdbe.org/5lqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqa RCSB], [http://www.ebi.ac.uk/pdbsum/5lqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqa ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
+__TOC__
+</StructureSection>
+[[Category: Catechol O-methyltransferase]]
 [[Category: Ehler, A]]
 [[Category: Ellermann, M]]
-[[Category: Rudolph, M.G]]
+[[Category: Rudolph, M G]]
+[[Category: Methyltransferase]]
+[[Category: Neurotransmitter degradation]]
+[[Category: Transferase]]